LABORATORY OF HUMAN ENDOCRINOLOGY (LHE)

Scientific directions of the laboratory

• The centre of research activities concerns physiological processes in healthy subjects as well as pathophysiological mechanisms and the role hormones play in metabolism and chronic inflammation both in selected endocrine and nonendocrine diseases (diabetes mellitus type 2, hypertension, metabolic syndrome, rheumatoid arthritis, systemic sclerosis). Examination procedures applied in the Laboratory include: the technique of insulin clamps, biopsy of adipose tissue, microdialysis of adipose tissue, insulin hypoglycemia, orthostatic tests, pharmacological tests, analysis of heart rate variability, etc.

The most important publications of workers of the Laboratory of human endocrinology (IF ≥3)

1. Toledo FG, Menshikova EV, Azuma K, Radiková Z, Kelley CA, Ritov VB, Kelley DE. Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content. Diabetes. 2008 Apr;57(4):987-94. IF(2008)=8,398

2. Imrich R, Rovensky J, Malis F, Zlnay M, Tillinger Z, Kvetnansky R, Huckova M, Vigas M, Macho L, Koska J. Low levels of dehydroepiandrosterone sulphate in plasma, and reduced sympathoadrenal response to hypoglycaemia in premenopausal women with rheumatoid arthritis.Ann Rheum Dis. 2005 Feb;64(2):202 IF(2005)=6.95

3. Penesova A, Bunt JC, Bogardus C, Krakoff J. Effect of paternal diabetes on pre-diabetic phenotypes in adult offspring. Diabetes Care. 2010 Aug;33(8):1823-8. IF (2009)=6,718

4. Ukropec J, Radikova Z, Huckova M, Koska J, Kocan A, Sebokova E, Drobna B, Trnovec T, Susienkova K, Labudova V, Gasperikova D, Langer P, Klimes I. High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail. Diabetologia. 2010 May;53(5):899-906. IF (2009)=6,551

5.Chomentowski P, Coen PM, Radiková Z, Goodpaster BH, Toledo FG. Skeletal muscle mitochondria in insulin resistance: differences in intermyofbrillar versus subsarcolemmal subpopulations and relationship to metabolic fexibility. J Clin Endocrinol Metab. 2011 Feb;96(2):494-503. IF (2009)=6,202

6. Goldstein DS, Imrich R, Peckham E, Holmes C, Lopez G, Crews C, Hardy J, Singleton A, Hallett M. Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation. Neurology. 2007 Oct 16;69(16):1580-4. IF(2007)=6.014

7. Ukropec J, Penesová A, Skopkova M, Pura M, Vlcek M, Radikova Z, Imrich R, Ukropcova B, Tajtáková M, Koska J, Zórad S, Belan V, Vanuga P, Payer J, Eckel J, Klimes I, Gasperíková D. Adipokine protein expression pattern in growth hormone deffciency predisposes to the increased fat cell size and the whole body metabolic derangements. J Clin Endocrinol Metab. 2008 Jun;93(6):2255-62. IF(2007)=5,493

8. Imrich R, Rovensky J, Zlnay M, Radikova Z, Macho L, Vigas M, Koska J. Hypothalamicpituitary-adrenal axis function in ankylosing spondylitis.Ann Rheum Dis. 2004 Jun;63(6):671-4. IF(2005)=3.916

9. Rádiková Z, Tajtáková M, Kocan A, Trnovec T, Seböková E, Klimes I, Langer P. Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia. Thyroid. 2008 Mar;18(3):353-62 IF(2008)=3,000