LABORATORY OF DIABETES and METABOLIC DERANGEMENTS (LDaMD)

Scientific directions of the laboratory

• Research is focused on genetics of monogenic forms of diabetes and on molecular mechanisms of obesity and insulin resistance development. The aim is to provide genetic diagnosis of different forms of monogenic diabetes for the patients with diabetes and their families throughout Slovakia. Subjects with different subtypes of monogenic diabetes are actively searched, and their DNA stored in the DNA repository. In newly identified mutations, the pathomechanism of diabetes development has been studied. In clinical studies, research is focused on the endocrine role of adipose tissue in relation to molecular mechanisms involved to the development of insulin resistance, obesity and diabetes. Metabolic pathways are investigated in patients with different tolerance of glucose and in patients with growth hormone deficit. Molecular biology processes of patients with obesity and/or diabetes are investigated by the most up-to-date methods of genomics, transcriptomics, and lipidomics.